| Central | Casper Service Road | | WY 259 | Ormsby Road |
| I 25 | | Glenrock | Casper |
| I 25 / US 87 | | Casper | Exit 210, Horse Ranch Creek Rd |
| US 20/26 | | Shoshoni | Moneta |
| | Moneta | Waltman |
| | Waltman | Casper |
| US 20/26/87 | | Glenrock | Casper |
| US 287 / WY 789 | | Mile Marker 23 | Lamont |
| | Lamont | Muddy Gap |
| | Muddy Gap | Jeffrey City |
| | Jeffrey City | Sweetwater Station Jct |
| | Sweetwater Station Jct | Jct WY 28 / US 287 |
| WY 220 | | Muddy Gap | Independence Rock |
| | Independence Rock | Pathfinder Rd |
| | Pathfinder Rd | Alcova |
| | Alcova | WY 487 |
| | WY 487 | Casper |
| WY 257 | | WY 220 | Robertson Road |
| | Robertson Road | US 20/26 |
| WY 258 | | Mills | Evansville |
| Northeast | I 25 / US 87 | | Exit 210, Horse Ranch Creek Rd | Exit 227, WY 387 |
| | Exit 227, WY 387 | Exit 235, Tisdale Mtn Rd |
| | Exit 235, Tisdale Mtn Rd | Kaycee |
| | Kaycee | Exit 265, Reno Rd |
| | Exit 265, Reno Rd | Buffalo |
| WY 196 | | I-25 | Kaycee |
| | Kaycee | Beaver Creek |
| | Beaver Creek | Buffalo |
| Northwest | US 14/16/20 | | Pahaska | the Shoshone National Forest Boundary |
| | the Shoshone National Forest Boundary | Cody |
| US 14 A | | Cody | Powell |
| US 212 | | Mile Marker 4.5, Westbound Closure Gate | WY 296 |
| WY 120 | | WY 171 | Meeteetse |
| | Meeteetse | Cody |
| WY 296 | | US 212 | WY 120 |
| Southeast | Cheyenne Service Road | | Archer Interchange | WY 217 |
| Chugwater Service Road | | Laramie County Line | WY 321 |
| I 25 / US 20/26/87 | | Douglas | Glenrock |
| I 25 / US 26/87 | | Exit 92, US 26 | Glendo |
| | Glendo | Exit 126, US 18/20 |
| I 25 / US 87 | | the Colorado State Line | Cheyenne |
| | Cheyenne | Exit 29, Whitaker Rd |
| | Exit 29, Whitaker Rd | Chugwater |
| | Chugwater | Exit 73, WY 34 |
| | Exit 73, WY 34 | Wheatland |
| | Wheatland | Exit 92, US 26 |
| I 80 | | Exit 235, Walcott Jct | Exit 255, WY 72 |
| | Exit 255, WY 72 | Exit 267, Wagonhound Rd |
| | Exit 267, Wagonhound Rd | Arlington |
| | Arlington | Exit 279, Cooper Cove Rd |
| | Exit 279, Cooper Cove Rd | Exit 290, Quealy Dome |
| | Exit 290, Quealy Dome | Laramie |
| I 80 / US 30 | | Laramie | Exit 323, Happy Jack Rd |
| | Exit 323, Happy Jack Rd | Exit 335, Buford |
| | Exit 335, Buford | Exit 348, Otto Rd |
| | Exit 348, Otto Rd | Exit 359, Junction I-25 |
| | Exit 359, Junction I-25 | Exit 364, College Drive |
| | Exit 364, College Drive | Exit 370, Archer Interchange |
| | Exit 370, Archer Interchange | Exit 377, WY 217 |
| | Exit 377, WY 217 | Pine Bluffs |
| I 80 / US 30/287 | | Rawlins | Exit 235, Walcott Jct |
| I 80 / US 30 / WY 789 | | Exit 187, Creston Jct | Rawlins |
| US 26 | | I-25, Dwyer Jct | Guernsey |
| | Guernsey | Lingle |
| | Torrington | the Nebraska State Line |
| US 26/85 | | Torrington | Lingle |
| US 287 | | the Colorado State Line | Start of Divided Highway, Mile Marker 416 |
| | Start of Divided Highway, Mile Marker 416 | Mile Marker 413, 4 Miles North of Tie Siding |
| | Mile Marker 413, 4 miles north of Tie Siding | Laramie |
| US 287 / WY 789 | | Rawlins | Mile Marker 23 |
| US 30/287 | | I-80, Walcott Jct | Hanna Jct |
| | Hanna Jct | Medicine Bow |
| | Medicine Bow | Rock River |
| | Rock River | Divided Highway at Mile Marker 290 |
| | Divided Highway at Mile Marker 290 | Divided Highway at Mile Marker 308 |
| | Divided Highway at Mile Marker 308 | WY 34, Closure Gate |
| | WY 34, Closure Gate | Laramie |
| US 85 | | the Colorado State Line | Cheyenne |
| | Cheyenne | Meriden |
| | Meriden | WY 151, Bear Mountain Station |
| | WY 151, Bear Mountain Station | WY 161, Silvertip |
| | WY 161, Silvertip | Torrington |
| | Lingle | Jay Em |
| WY 10 | | Woods Landing | the Colorado State Line |
| WY 11 | | WY 130 | Albany |
| WY 12 | | WY 130 | Mandel Lane |
| WY 13 | | Rock River | Arlington |
| WY 130 | | I-80, Walcott Jct | WY 230 |
| | Green Rock | Centennial |
| | Centennial | WY 130/230 |
| WY 210 | | Cheyenne | Mile Marker 16, County Rd 109, Table Mtn Rd |
| | Mile Marker 16, County Rd 109, Table Mtn Rd | Curt Gowdy State Park |
| | Curt Gowdy State Park | I-80 |
| WY 211 | | WY 219, Yellowstone Rd | Jordan Road |
| WY 212 | | I-25, Cheyenne | East Four Mile Rd |
| | College Dr | WY 219, Yellowstone Rd |
| WY 213 | | I-80 | US 85 |
| WY 216 | | US 85 | the Nebraska State Line |
| WY 222 | | WY 225, Otto Rd | WY 211, Horse Creek Rd |
| WY 225 | | I-80, Otto Rd | Cheyenne |
| WY 230 | | Riverside | the Colorado State Line |
| | the Colorado State Line | Woods Landing |
| | Woods Landing | Laramie |
| WY 270 | | Guernsey | the Niobrara/Platte Cty Line |
| WY 313 | | Chugwater | US 85 |
| WY 319 | | I-25 / US 26/87 | US 18/20 |
| | Glendo | Jct US 18/20 |
| WY 320 | | Wheatland | Grey Rocks Closure Gate |
| | Grey Rocks Closure Gate | US 26 |
| WY 321 | | Chugwater | I-25 |
| WY 34 | | Bosler | Morton Pass |
| | Morton Pass | the Platte/Albany County Line |
| | the Platte/Albany Cty Line | Tally Ho Ranch |
| | Tally Ho Ranch | I-25 |
| WY 487 | | Medicine Bow | the South Jct WY 77 |
| | the South Jct WY 77 | the North Jct WY 77 |
| | the North Jct WY 77 | WY 220 |
| WY 72 | | I-80 | Hanna Jct |
| WY 77 | | the South Jct WY 487 | Mile Marker 132, Northbound Closure Gate |
| | Mile Marker 132, Northbound Closure Gate | Mile Marker 142, Southbound Closure Gate |
| | Mile Marker 142, Southbound Closure Gate | the North Jct WY 487 |
| Southwest | I 80 | | Exit 18, US 189 | Exit 30, Bigelow Rd |
| | Exit 30, Bigelow Rd | Exit 39, WY 412/414 |
| | Exit 39, WY 412/414 | MM 57, Sweetwater County Line |
| | MM 57, Uinta County Line | Exit 66, Granger Jct |
| I 80 / US 189 | | Evanston | Exit 18, US 189 |
| I 80 / US 30 | | Exit 66, Granger Jct | Exit 83, La Barge Rd |
| | Exit 83, La Barge Rd | Exit 91, Flaming Gorge Way |
| | Exit 91, Flaming Gorge Way | Exit 104, Rock Springs |
| | Exit 104, Rock Springs | Exit 111, Airport and Baxter Roads |
| | Exit 111, Airport and Baxter Roads | Point of Rocks |
| | Point of Rocks | Exit 142, Bitter Creek |
| | Exit 142, Bitter Creek | Exit 158, Tipton Rd |
| | Exit 158, Tipton Rd | Wamsutter |
| | Wamsutter | Exit 187, Creston Jct |
| US 191 | | Mile Marker 513 | Mile Marker 502, Southbound Closure Gate |
| | the Utah State Line | Mile Marker 513 |
| | Rock Springs | Mile Marker 12, Yellowstone Rd |
| | Mile Marker 12, Yellowstone Rd | Farson |
| | Farson | WY 351 |
| US 30 | | Sage Jct | Mile Marker 38, County Rd 209 |
| | Mile Marker 38, County Rd 209 | Kemmerer |
| US 30 / WY 89 | | Cokeville | Sage Jct |
| WY 28 | | WY 372 | Farson |
| | Farson | the Fremont/Sublette Cty Line |
| | the Fremont/Sublette Cty Line | Mile Marker 47 |
| | Mile Marker 47 | Mile Marker 63, Westbound Closure Gate |
| | Mile Marker 63, Westbound Closure Gate | US 287 / WY 789 |
| WY 371 | | I-80 | Superior |
| WY 372 | | WY 28 | US 189 |
| WY 374 | | WY 372 | Green River |
| WY 410 | | Mountain View | End of State Route |
| WY 411 | | WY 410 | Millburne |
| WY 412 | | I-80 | US 189 |
| WY 414 | | I-80, Carter Int | the Utah State Line |
| WY 430 | | Rock Springs | the Colorado State Line |
| WY 70 | | WY 789 | Mile Marker 22 |
| | Mile Marker 22 | Mile Marker 27, Eastbound Closure Gate |
| WY 789 | | Colorado State Line | Mile Marker 25 |
| | Mile Marker 25 | I-80, Creston Junction |
| WY 89 | | the Utah State Line | Sage Jct |