| Central | Casper Service Road | | WY 259 | Ormsby Road |
| I 25 | | Glenrock | Casper |
| I 25 / US 87 | | Casper | Exit 210, Horse Ranch Creek Rd |
| US 20/26 | | Shoshoni | Moneta |
| | Moneta | Waltman |
| | Waltman | Casper |
| US 20/26/87 | | Glenrock | Casper |
| US 20 / WY 789 | | Mile Marker 148, Washakie/Hot Springs County Line | Thermopolis |
| | Thermopolis | Boysen Dam |
| | Boysen Dam | Shoshoni |
| US 26 | | Diversion Dam Jct | Riverton |
| US 26 / WY 789 | | Riverton | WY 134 |
| | WY 134 | Shoshoni |
| US 287 | | Lander | Diversion Dam Jct |
| US 287 / WY 789 | | Mile Marker 23 | Lamont |
| | Lamont | Muddy Gap |
| | Muddy Gap | Jeffrey City |
| | Jeffrey City | Sweetwater Station Jct |
| | Sweetwater Station Jct | Jct WY 28 / US 287 |
| | Jct WY 28 / US 287 | Lander |
| WY 120 | | Thermopolis | WY 171 |
| WY 131 | | Lander | Sinks Canyon State Park |
| WY 132 | | US 287 | Ethete |
| | Ethete | US 26 |
| WY 133 | | Kinnear | Pavillion |
| WY 134 | | US 26 / WY 789 | WY 133 |
| WY 135 | | WY 789 | WY 139 |
| | WY 139 | Sweetwater Station Jct |
| WY 136 | | WY 135 | Gas Hills |
| WY 220 | | Muddy Gap | Independence Rock |
| | Independence Rock | Pathfinder Rd |
| | Pathfinder Rd | Alcova |
| | Alcova | WY 487 |
| | WY 487 | Casper |
| WY 251 | | WY 258, Wyoming Blvd | End of State Route |
| WY 257 | | WY 220 | Robertson Road |
| | Robertson Road | US 20/26 |
| WY 258 | | Mills | Evansville |
| WY 789 | | Lander | Hudson |
| | Hudson | Riverton |
| Northeast | I 25 / US 87 | | Exit 210, Horse Ranch Creek Rd | Exit 227, WY 387 |
| | Exit 227, WY 387 | Exit 235, Tisdale Mtn Rd |
| | Exit 235, Tisdale Mtn Rd | Kaycee |
| | Kaycee | Exit 265, Reno Rd |
| | Exit 265, Reno Rd | Buffalo |
| I 90 | | Sheridan | Exit 44, Piney Creek Rd |
| | Buffalo | the Johnson/Campbell County Line |
| | the Johnson/Campbell County Line | Gillette |
| | Moorcroft | Exit 165, Pine Ridge Rd |
| | Exit 165, Pine Ridge Rd | Sundance |
| I 90 / US 14 | | Sundance | the South Dakota State Line |
| I 90 / US 14/16 | | Gillette | Rozet |
| | Rozet | Moorcroft |
| I 90 / US 87 | | Exit 44, Piney Creek Rd | Buffalo |
| US 14 | | Antelope Butte Mountain Recreation Area | Elk View |
| | Elk View | Steamboat Rock |
| | Steamboat Rock | Dayton School |
| | Dayton | Ranchester |
| | Sheridan | Ucross |
| | Moorcroft | WY 113 |
| | WY 113 | Carlile |
| | Carlile | WY 24 |
| | WY 24 | Sundance |
| US 14/16 | | Ucross | Mile Marker 60, the Sheridan/Campbell County Line |
| | Mile Marker 60, the Sheridan/Campbell County Line | WY 59 |
| US 14/16 / WY 59 | | WY 59 | Gillette |
| US 16 | | Deer Haven Lodge | Canyon Creek Rd |
| | Canyon Creek Rd | Sheep Mountain Rd |
| | Sheep Mountain Rd | Hunter Ranger Station |
| | Hunter Ranger Station | Buffalo |
| | Buffalo | Ucross |
| | Moorcroft | Weston/Crook County Line |
| | Weston/Crook County Line | Upton |
| US 212 | | the Montana State Line | the South Dakota State Line |
| US 85 | | Newcastle | WY 585, Four Corners |
| | WY 585, Four Corners | the South Dakota State Line |
| US 87 | | Banner | Sheridan |
| WY 110 | | WY 24 | Devils Tower Nat'l Monument |
| WY 112 | | Hulett | Strawberry Hill |
| | Strawberry Hill | the Montana State Line |
| WY 113 | | US 14 | Pine Haven |
| WY 192 | | Kaycee | Linch |
| | Linch | WY 387 |
| WY 194 | | Story | End of State Route |
| WY 196 | | I-25 | Kaycee |
| | Kaycee | Beaver Creek |
| | Beaver Creek | Buffalo |
| WY 24 | | US 14 | Hulett |
| | Hulett | the east side of Bear Lodge |
| WY 259 | | I-25 | Midwest |
| WY 331 | | Sheridan | Beckton |
| WY 332 | | Sheridan | WY 334 |
| WY 335 | | US 87 | Red Grade Rd |
| WY 336 | | Sheridan | Dutch Creek Rd |
| WY 338 | | Sheridan | the Montana State Line |
| WY 340 | | Story | North Piney Creek |
| WY 343 | | WY 345 | Dayton |
| WY 345 | | the Montana State Line | Ranchester |
| | Ranchester | I-90 |
| WY 387 | | Midwest | Pine Tree Jct |
| | Pine Tree Jct | Wright |
| | Wright | Reno Jct |
| WY 450 | | the Campbell/Weston County Line | Mile Marker 54, Eastbound Closure Gate |
| | Mile Marker 54, Eastbound Closure Gate | WY 59 |
| WY 50 | | Gillette | Mile Marker 12, Clarkelen Rd Closure Gate |
| | Mile Marker 12, Clarkelen Rd Closure Gate | Pine Tree Junction |
| WY 51 | | Gillette | Rozet |
| | Rozet | Moorcroft |
| WY 585 | | Four Corners | Crook/Weston County Line |
| WY 59 | | the Campbell/Converse Cty Line | Mile Marker 67, Edwards Rd |
| | Mile Marker 67, Edwards Rd | Wright |
| | Wright | Mile Marker 94, Haight Rd |
| | Mile Marker 94, Haight Rd | Gillette |
| | US 14/16 | Mile Marker 126, Northbound Closure Gate |
| | Mile Marker 126, Northbound Closure Gate | the Montana State Line |
| Northwest | US 14 | | Greybull | Shell |
| | Shell | Antelope Butte Mountain Recreation Area |
| US 14/16/20 | | Pahaska | the Shoshone National Forest Boundary |
| | the Shoshone National Forest Boundary | Cody |
| | Cody | the Big Horn County Line |
| | the Big Horn County Line | 4 miles west of Greybull |
| US 14/16/20/310 / WY 789 | | Greybull | 4 miles west of Greybull |
| US 14 A | | Cody | Powell |
| | Powell | the West Jct US 310 / WY 789 |
| | Lovell | 22 miles east of Lovell |
| US 14A/310 | | Lovell | the West Jct US 310 / WY 789 |
| US 16/20 / WY 789 | | Greybull | Basin |
| | Basin | MM 176, Washakie/Big Horn County Line |
| | Washakie/Big Horn County Line | Worland |
| US 189/191 | | Bondurant | Hoback Jct |
| US 20 / WY 789 | | Worland | Mile Marker 148, Washakie/Hot Springs County Line |
| US 212 | | Mile Marker 4.5, Westbound Closure Gate | WY 296 |
| US 26/287 | | Dubois | Diversion Dam Jct |
| US 26/89 | | Alpine Jct | Hoback Jct |
| US 26/89/189/191 | | Hoback Jct | Jackson |
| US 26/89/191 | | Jackson | the S Boundary of Grand Teton Nat'l Park |
| US 310 / WY 789 | | 4 miles west of Greybull | Lovell |
| | US 310 / WY 789 | the Montana State Line |
| WY 114 | | Garland | Deaver |
| WY 120 | | WY 171 | Meeteetse |
| | Meeteetse | Cody |
| | Cody | the Montana State Line |
| WY 22 | | Jackson | Wilson |
| WY 296 | | US 212 | WY 120 |
| WY 390 | | WY 22 | Teton Village |
| WY 431 | | US 20 / WY 789/432 | WY 120 |
| Southeast | Cheyenne Service Road | | Archer Interchange | WY 217 |
| I 25 / US 20/26/87 | | Douglas | Glenrock |
| I 80 / US 30 | EASTBOUND | Laramie | Exit 323, Happy Jack Rd |
| EASTBOUND | Exit 323, Happy Jack Rd | Exit 335, Buford |
| EASTBOUND | Exit 335, Buford | Exit 348, Otto Rd |
| EASTBOUND | Exit 348, Otto Rd | Exit 359, Junction I-25 |
| | Exit 359, Junction I-25 | Exit 364, College Drive |
| | Exit 364, College Drive | Exit 370, Archer Interchange |
| | Exit 370, Archer Interchange | Exit 377, WY 217 |
| | Exit 377, WY 217 | Pine Bluffs |
| I 80 / US 30 / WY 789 | | Exit 187, Creston Jct | Rawlins |
| US 18/20 | | I-25, Orin Jct | Lost Springs |
| | Lost Springs | Lusk |
| US 18/85 | | Lusk | Mule Creek Jct |
| US 20 | | Lusk | the Nebraska State Line |
| US 26 | | I-25, Dwyer Jct | Guernsey |
| | Guernsey | Lingle |
| | Torrington | the Nebraska State Line |
| US 26/85 | | Torrington | Lingle |
| US 287 | | the Colorado State Line | Start of Divided Highway, Mile Marker 416 |
| | Start of Divided Highway, Mile Marker 416 | Mile Marker 413, 4 Miles North of Tie Siding |
| | Mile Marker 413, 4 miles north of Tie Siding | Laramie |
| US 287 / WY 789 | | Rawlins | Mile Marker 23 |
| US 30/287 | | Rock River | Divided Highway at Mile Marker 290 |
| | Divided Highway at Mile Marker 308 | WY 34, Closure Gate |
| US 85 | | Lingle | Jay Em |
| | Jay Em | Lusk |
| WY 10 | | Woods Landing | the Colorado State Line |
| WY 11 | | WY 130 | Albany |
| WY 12 | | WY 130 | Mandel Lane |
| WY 13 | | Rock River | Arlington |
| WY 130 | | I-80, Walcott Jct | WY 230 |
| | Green Rock | Centennial |
| | Centennial | WY 130/230 |
| WY 210 | | Cheyenne | Mile Marker 16, County Rd 109, Table Mtn Rd |
| | Mile Marker 16, County Rd 109, Table Mtn Rd | Curt Gowdy State Park |
| | Curt Gowdy State Park | I-80 |
| WY 211 | | WY 219, Yellowstone Rd | Jordan Road |
| WY 212 | | I-25, Cheyenne | East Four Mile Rd |
| | College Dr | WY 219, Yellowstone Rd |
| WY 213 | | I-80 | US 85 |
| WY 216 | | US 85 | the Nebraska State Line |
| WY 222 | | WY 225, Otto Rd | WY 211, Horse Creek Rd |
| WY 225 | | I-80, Otto Rd | Cheyenne |
| WY 230 | | Riverside | the Colorado State Line |
| | the Colorado State Line | Woods Landing |
| | Woods Landing | Laramie |
| WY 270 | | Guernsey | the Niobrara/Platte Cty Line |
| | the Niobrara/Platte Cty Line | Manville |
| | Manville | US 18/85 |
| WY 313 | | Chugwater | US 85 |
| WY 320 | | Wheatland | Grey Rocks Closure Gate |
| | Grey Rocks Closure Gate | US 26 |
| WY 34 | | Bosler | Morton Pass |
| | Morton Pass | the Platte/Albany County Line |
| | the Platte/Albany Cty Line | Tally Ho Ranch |
| | Tally Ho Ranch | I-25 |
| WY 487 | | Medicine Bow | the South Jct WY 77 |
| | the South Jct WY 77 | the North Jct WY 77 |
| | the North Jct WY 77 | WY 220 |
| WY 59 | | WY 94, Douglas | the Campbell/Converse Cty Line |
| WY 72 | | I-80 | Hanna Jct |
| WY 77 | | the South Jct WY 487 | Mile Marker 132, Northbound Closure Gate |
| | Mile Marker 132, Northbound Closure Gate | Mile Marker 142, Southbound Closure Gate |
| | Mile Marker 142, Southbound Closure Gate | the North Jct WY 487 |
| WY 93 | | Douglas | End of State Route |
| WY 95 | | Glenrock | WY 93 |
| Southwest | I 80 | | Exit 18, US 189 | Exit 30, Bigelow Rd |
| | Exit 30, Bigelow Rd | Exit 39, WY 412/414 |
| | Exit 39, WY 412/414 | MM 57, Sweetwater County Line |
| | MM 57, Uinta County Line | Exit 66, Granger Jct |
| I 80 / US 189 | | the Utah State Line | Evanston |
| | Evanston | Exit 18, US 189 |
| I 80 / US 30 | | Exit 66, Granger Jct | Exit 83, La Barge Rd |
| | Exit 83, La Barge Rd | Exit 91, Flaming Gorge Way |
| | Exit 91, Flaming Gorge Way | Exit 104, Rock Springs |
| | Exit 104, Rock Springs | Exit 111, Airport and Baxter Roads |
| | Exit 111, Airport and Baxter Roads | Point of Rocks |
| | Point of Rocks | Exit 142, Bitter Creek |
| | Exit 142, Bitter Creek | Exit 158, Tipton Rd |
| | Exit 158, Tipton Rd | Wamsutter |
| | Wamsutter | Exit 187, Creston Jct |
| US 189 | | WY 412 | Kemmerer |
| | Kemmerer | WY 372 |
| | WY 372 | La Barge |
| | La Barge | Big Piney |
| | Big Piney | Daniel Jct |
| US 189/191 | | Daniel Jct | Bondurant |
| US 191 | | Mile Marker 513 | Mile Marker 502, Southbound Closure Gate |
| | the Utah State Line | Mile Marker 513 |
| | Rock Springs | Mile Marker 12, Yellowstone Rd |
| | Mile Marker 12, Yellowstone Rd | Farson |
| | Farson | WY 351 |
| | WY 351 | Pinedale |
| | Pinedale | Daniel Jct |
| US 30 | | Sage Jct | Mile Marker 38, County Rd 209 |
| | Mile Marker 38, County Rd 209 | Kemmerer |
| | Kemmerer | Opal |
| | Opal | I-80, Granger Jct |
| US 30 / WY 89 | | Border Jct | Cokeville |
| | Cokeville | Sage Jct |
| | Border Jct | the Idaho State Line |
| WY 150 | | Evanston | the Utah State Line |
| WY 232 | | Cokeville | Button Flat |
| WY 233 | | Kemmerer | End of State Route |
| WY 235 | | La Barge | Calpet |
| WY 240 | | Opal | US 189 |
| WY 28 | | WY 372 | Farson |
| WY 350 | | Big Piney | End of State Route |
| WY 351 | | US 189 | US 191 |
| WY 352 | | US 191 | Bridger Teton Nat'l Forest |
| WY 353 | | US 191 | End of State Route |
| WY 371 | | I-80 | Superior |
| WY 372 | | I-80 | WY 28 |
| | WY 28 | US 189 |
| WY 374 | | I-80 | US 30 |
| | I-80, Little America | WY 372 |
| WY 410 | | Mountain View | End of State Route |
| WY 411 | | WY 410 | Millburne |
| WY 412 | | I-80 | US 189 |
| WY 414 | | I-80, Carter Int | the Utah State Line |
| WY 430 | | Rock Springs | the Colorado State Line |
| WY 530 | | Green River | the Utah State Line |
| WY 70 | | WY 789 | Mile Marker 22 |
| | Mile Marker 22 | Mile Marker 27, Eastbound Closure Gate |
| WY 789 | | Colorado State Line | Mile Marker 25 |
| | Mile Marker 25 | I-80, Creston Junction |
| WY 89 | | Evanston | the Utah State Line |
| | the Utah State Line | Sage Jct |